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KMID : 0369820110410040233
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Jorunal of Korean Pharmaceutical Sciences
2011 Volume.41 No. 4 p.233 ~ p.238
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Temperature and pH Stability Profiles of ortho and para DEET
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Choi Mi-Rine
Kim Seok-Yong
Choi Joon-Ho
Park Sang-Hee
Yong Chul-Soon
Kim Jung-Sun
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Abstract
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DEET, N,N'-diethyl-m-toluamide, is the most commonly used mosquito repellent. However, it can easily permeate through skin leading to toxic effects. A recent study showed that the ortho analogue of DEET showed enhanced repellency with reduced permeation compared to the commercially used meta analogue. Thus, in order to understand the differences in properties and effectiveness among the m-, o- and p-analogues of DEET, an HPLC-UV method was developed for separately analyzing the three analogues. Moreover, stability profiles at temperatures ranging from 30℃ to 70℃ as well as pH ranging from pH 3 to pH 9 have been determined. All three analogues were stable with no degradation observed during the 5 day period. o-DEET therefore could be further developed into a safer and more effective mosquito repellent.
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KEYWORD
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DEET, Temperature stability, pH stability, Mosquito repellency
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